LIST-S2 predicts the deleteriousness of amino acid mutations in proteomes. Prediction scores in the range [0 .. 1], where lower scores indicate more benign and higher indicate deleteriousness effect.
Per Mutation: To obtain LIST-S2 predictions for a list of mutations, copy and paste these mutations in the input text box and then click . Each entry should have the following format: AC:Pos:RefAA:AlleleAA
- AC: protein accession number.
- Pos: protein position.
- RefAA: the reference amino acid at position Pos.
- AlleleAA: the allele amino acid.
O08586:295:L:H
O08586:175:V:M
E1BMF7:727:Q:P
E1BMF7:727:Q:E
P07766:192:R:T
Output:
A0A0A0O08586:295:L:H 0.718928
O08586:175:V:M 0.997573
E1BMF7:727:Q:P 0.787321
E1BMF7:727:Q:E 0.929907
Per Protein: One can also visualize/download LIST-S2 scores for all possible mutations of a specific protein sequence identified by its accession number.
Enter an id value under Accession and then select:
Download: to download all scores, or
Matrix: to display an interactive matrix with all possible mutant amino acid scores
color coded.
To zoom in, use the mouse to select the region of interest, then one can zoom out
by clicking [Reset zoom].